Conversion of a Delayed Rectifier K+ Channel to a Voltage-Gated Inward Rectifier K+ Channel by Three Amino Acid Substitutions
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چکیده
منابع مشابه
Conversion of a Delayed Rectifier K+ Channel to a Voltage-Gated Inward Rectifier K+ Channel by Three Amino Acid Substitutions
Single, double, and triple mutations progressively shift Shaker activation to more hyperpolarized potentials, resulting in an increase in the fraction of inactivated channels at negative resting voltages. The most negatively shifted mutation, the triple mutant, behaves like an inward rectifier. What is usually considered activation of an inward rectifier is, for the triple mutant, recovery from...
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ژورنال
عنوان ژورنال: Neuron
سال: 1996
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(00)80105-1